Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana

Four new monotetrahydrofuranic Annonaceous acetogenins, montalicins G (1) and H (2) and monlicins A (3) and B (4), and two new linear acetogenins, (+)-monhexocin (5) and (−)-monhexocin (6), as well as three known compounds, murisolin (7), 4-deoxyannomontacin (8), and muricatacin (9), were isolated from the seeds of Annona montana by high performance liquid chromatographic (HPLC) method. The absolute stereochemical structures of new isolates were elucidated and characterized by spectral and chemical methods. Interestingly, these compounds show special cytotoxicity against human hepatoma cells, Hep G2.

Six new Announces acetogennins, montalicins G (1) and H (2), monlicins A (3) and B (4), (+)-monhexocin (5), and (−)-monhexocin (6), as well as three known Annonaeous acetogenins were isolated from the seeds of Annona montana by HPLC. The absolute stereochemical structures of nw isolates were elucidated and characterized by spectral and chemical methods. Interestingly, these compounds show special cytotoxicity against human hepatoma cells, Hep G2.Figure optionsDownload as PowerPoint slide