Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

Series of Schiff bases was prepared by condensing triazole with aromatic aldehydes. Aminomethylation of Schiff bases with secondary amines and substituted primary amines gave Mannich bases. Newly synthesized compounds were characterized by spectral data and elemental analysis. All compounds were tested for their antimicrobial activity.Figure optionsDownload as PowerPoint slide