Amphiphilic polyether branched molecules to increase the circulation time of cationic particles

The preparation, physicochemical and biological properties of amphiphilic polyether branched molecules is described. These ‘bunch shaped’ molecules when inserted into cationic liposomes/DNA complexes have shown efficient surface charge shielding. As a consequence they efficiently inhibited the non specific interactions with blood components and significantly enhanced circulation time of the particles in the blood track. Formulations containing these molecules compared positively with those containing PEG lipids, providing a 5-fold increase in circulation time.

Amphiphilic polyether ‘bunch shaped’ molecules such as 14 have shown efficient surface charge shielding when inserted into cationic liposomes/DNA complexes and significantly enhanced the circulation time of the particles in the blood track.Figure optionsDownload as PowerPoint slide