کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364623 981542 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives
چکیده انگلیسی

A series of podophyllotoxin and podophyllic aldehyde derivatives, lacking the lactone ring and oxidized at C-9 position, has been prepared. The functionalities considered at C-9 were carboxylic acids and several derivatives such as esters, amides, nitriles or anhydrides. The synthesized compounds were cytotoxic at the micromolar level, though less potent and selective than the parent compounds, revealing the influence of the C-9 electrophilic character on the potency and selectivity of these cyclolignans.

A series of cyclolignans oxidized at C-9 position has been prepared from the cytotoxic and selective podophyllic aldehyde. The functionalities considered at C-9 were carboxylic acids and several derivatives such as anhydrides, esters, nitriles or amides.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 4, 15 February 2007, Pages 1670–1678
نویسندگان
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