کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364636 981542 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dicationic derivatives of DBTAA: Interactions with DNA/RNA and antiproliferative effects on human cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The dicationic derivatives of DBTAA: Interactions with DNA/RNA and antiproliferative effects on human cell lines
چکیده انگلیسی

Three dibenzotetraaza[14]annulenes non-covalently interacted with double-stranded DNA and RNA by mixed minor groove and/or intercalative binding mode. Observed interactions were strongly dependent on the steric exposure of positive charges and the length of the linkers of studied compounds as well as on the secondary structure and basepair composition of DNA/RNA. Compound 2 showed pronounced selectivity toward dA–dT-rich sequences and binding mode switch from dominant minor groove binding to ds-DNA to dominant intercalation into ds-RNA. Antiproliferative effect of studied compounds on human tumor and normal cell lines was in good agreement with the strength of observed interactions with DNA/RNA.

Bis-cationic derivatives of dibenzotetraaza[14]annulene(1–3).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 4, 15 February 2007, Pages 1795–1801
نویسندگان
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