کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364746 981545 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules
چکیده انگلیسی

Several novel catechin/epicatechin and nucleobase chimeric molecules 1–6 have been synthesized via azide-alkyne click chemistry. The structures of these hybrids have been confirmed by NMR and mass spectroscopic data. The synthesized molecules were tested for their RNase A inhibition activities. Gel-based assays showed inhibition in micromolar concentrations. The extent of inhibition was found to be dependent upon the nature of base as well as the configuration at C-3 position of catechin.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 20, 15 October 2008, Pages 5411–5414
نویسندگان
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