کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364882 | 981548 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes](/preview/png/1364882.png)
چکیده انگلیسی
To expand the function of DNA machines, we constructed a non-DNA-fuel machine based on the G-quadruplex and i-motif structures within the telomere DNA sequence. Depending on the binding or non-binding of the specified form, the DNA machine is able to bind or release the telomere-binding protein TRF 1, and to release small quadruplex-binding molecules to impede progress of the polymerase. This DNA machine, driven by pH change, does not accumulate duplex DNA waste products to poison the system. These new functions undertaken by structured nucleic acids open many opportunities to create and expand the further functions and use of DNA and RNA.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 3, 1 February 2007, Pages 1275–1279
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 3, 1 February 2007, Pages 1275–1279
نویسندگان
Yan Xu, Yuuka Hirao, Yoshifumi Nishimura, Hiroshi Sugiyama,