کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364921 | 981549 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Epolactaene, a neuritogenic compound in human neuroblastoma SH-SY5Y, induces apoptosis in a human leukemia B-cell line, BALL-1. The apoptosis-inducing activities of 34 epolactaene derivatives, including those of the newly synthesized α-alkyl-α,β-epoxy-γ-lactam derivative and cyclopropane derivatives, were also tested. The structure–activity relationships of the epolactaene derivatives as an inducer of apoptosis are described. The α-acyl-α,β-epoxy-γ-lactam moiety as well as the hydrophobicity derived from the long alkyl side chain are both important for activity. Compound 1e displayed the strongest activity among all the synthesized compounds with an IC50 value of 0.70 μM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 7, 1 April 2006, Pages 2151–2161
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 7, 1 April 2006, Pages 2151–2161
نویسندگان
Kouji Kuramochi, Rie Matsui, Yasuaki Matsubara, Junko Nakai, Takashi Sunoki, Satoshi Arai, Seigo Nagata, Yukitoshi Nagahara, Yoshiyuki Mizushina, Masahiko Ikekita, Susumu Kobayashi,