کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364924 981549 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel α-aminophosphonic acids. Design, characterization, and biological activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel α-aminophosphonic acids. Design, characterization, and biological activity
چکیده انگلیسی

Novel α-aminophosphonic acids are synthesized reacting 1,3-oxazolidin-2-one derivatives with formaldehyde and phosphorus trichloride. Treatment of N-(phosphonomethyl)oxazolidinones with aqueous NaOH gave the expected α-aminophosphonic acids. The oxidation of (2-hydroxy-1,1-dimethylethylamino)methyl phosphonic acid in the presence of CdO and water resulted in N-phosphonomethyl-2-methyl-1-propanoic acid. Their structures were proved by means of IR, 1H, 13C, and 31P NMR spectroscopy. The genotoxic, clastogenic, and antiproliferative effects of newly synthesized original aminophosphonic acids were investigated for the first time.

The genotoxic, clastogenic and antiproliferative effects of newly synthesized original aminophosphonic acids were investigated for the first time.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 7, 1 April 2006, Pages 2190–2196
نویسندگان
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