Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET

(R)-OHDMI and CFMME were synthesized and found to be potent NET inhibitors. Each was labelled with carbon-11 (t1/2 = 20.4 min) as a prospective radioligand for imaging brain NETs with PET.