Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

Cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized. The compounds inhibited the growth of human tumor cells through induction of apoptosis and arresting cell cycle at G2/M phase.Figure optionsDownload as PowerPoint slide