کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365887 981575 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
چکیده انگلیسی

Following our previous publication describing the biological profiles, we herein describe the structure–activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 19, 1 October 2007, Pages 5472–5478
نویسندگان
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