Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia

Three new glabretal-type triperpenoids, aglaiaglabretols A-C, and nine known compounds, were isolated from the bark of Aglaia crassinervia. The cytotoxic activity of all isolates and several chemical transformation products was evaluated. The known cyclopenta[b]benzofuran, rocaglaol, was found to be significantly cytotoxic and comparable in potency to the positive controls, paclitaxel and camptothecin. Aglaiaglabretol B (2) was further tested in an in vivo hollow fiber model.