Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid

A novel bridged nucleic acid (BNA) analogue, 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNACOC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNACOC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.

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