QSAR study on para-substituted aromatic sulfonamides as carbonic anhydrase II inhibitors using topological information indices

A linear quantitative structure–activity relationship has been developed for a series of para-substituted aromatic sulfonamides by using topological index methodologies. The compounds were studied for their carbonic anhydrase II (CAII) inhibitory activity. A large series of topological indices were calculated and the stepwise regression method was used to derive the most significant model. Very good results were obtained using multi-parametric regressions and showed that the information approach used in the present work is quite useful for modeling carbonic anhydrase inhibition.

A QSAR study on para-substituted sulfonamide carbonic anhydrase inhibitors is performed using topological information indices. Different statistically significant multiparametric models have shown that the physiologically relevant isoform CA II can be successfully modeled using this topological information approach.Figure optionsDownload as PowerPoint slide