کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366089 | 981580 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Agonist lead identification for the high affinity niacin receptor GPR109a
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization.
A strategy for lead identification of new agonists of GPR109a is described. Early compound triage led us to focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 17, 1 September 2007, Pages 4914–4919
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 17, 1 September 2007, Pages 4914–4919
نویسندگان
Tawfik Gharbaoui, Philip J. Skinner, Young-Jun Shin, Claudia Averbuj, Jae-Kyu Jung, Benjamin R. Johnson, Tracy Duong, Marc Decaire, Jane Uy, Martin C. Cherrier, Peter J. Webb, Susan Y. Tamura, Ning Zou, Nathalie Rodriguez, P. Douglas Boatman,