The identification of potent, selective, and bioavailable cathepsin S inhibitors

Highly potent, selective, and bioavailable inhibitors of human, mouse, or rat cathepsin S are described. The key structural features combine a sulfonyl moiety attached to a large group in P2 and a small substituent in P3.

The Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Qué., Canada H9H 3L1.Figure optionsDownload as PowerPoint slide