کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366159 | 981582 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway](/preview/png/1366159.png)
چکیده انگلیسی
Investigation on the use of the oxidized form (factor 3 (3a)) of the trimethylated intermediate (precorrin 3 (2)) as a substrate for the enzymes of the anaerobic pathway to vitamin B12 led to the synthesis of three pairs of novel cobalt corrinoids. The products were made with the aid of the Salmonella typhimurium enzymes CbiH, CbiF, CbiG, and CbiT, were synthesized in several 13C labeled versions, and were isolated as methylesters after esterification. Structures were determined by detailed NMR and MS analyses. Each set of products was obtained in the decarboxylated (RMe) and non-decarboxylated (RCH2COOCH3) forms (at the C-12 position of the porphyrinoid).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 3, 1 February 2006, Pages 724-731
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 3, 1 February 2006, Pages 724-731
نویسندگان
Patricio J. Santander, Yasuhiro Kajiwara, Howard J. Williams, A. Ian Scott,