Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure–activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.

A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure–activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.Figure optionsDownload as PowerPoint slide