کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366453 981592 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters
چکیده انگلیسی

The extracts of Inula britannica have anti-inflammatory, anti-bacterial, anti-hepatitic, and anti-tumor activities. Various sesquiterpene lactones with cytotoxic properties including 1-O-acetylbritannilactone (1) have been isolated from this Chinese medicinal plant. Eight derivatives of 1-O-acetylbritannilactone, (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters were designed and synthesized. Four of these compounds were tested to show inhibitory activity on the growth of human leukemia HL-60 and cancer Bel-7402 cell lines.

Eight derivatives of 1-O-acetylbritannilactone, (2-O-alkyloxime-3-phenyl) propionyl-1-O-acetylbritannilactone ester are designed and synthesized. Four of these compounds were tested to show inhibitory activity on the growth of human HL-60 and Bel-7402 cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 8, 15 April 2005, Pages 2783–2789
نویسندگان
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