کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1366453 | 981592 | 2005 | 7 صفحه PDF | دانلود رایگان |

The extracts of Inula britannica have anti-inflammatory, anti-bacterial, anti-hepatitic, and anti-tumor activities. Various sesquiterpene lactones with cytotoxic properties including 1-O-acetylbritannilactone (1) have been isolated from this Chinese medicinal plant. Eight derivatives of 1-O-acetylbritannilactone, (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters were designed and synthesized. Four of these compounds were tested to show inhibitory activity on the growth of human leukemia HL-60 and cancer Bel-7402 cell lines.
Eight derivatives of 1-O-acetylbritannilactone, (2-O-alkyloxime-3-phenyl) propionyl-1-O-acetylbritannilactone ester are designed and synthesized. Four of these compounds were tested to show inhibitory activity on the growth of human HL-60 and Bel-7402 cell lines.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 8, 15 April 2005, Pages 2783–2789