کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366469 | 981592 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation](/preview/png/1366469.png)
چکیده انگلیسی
Prepared from a commercial prostaglandin building block, novel vitamin D3 analogs with a contracted five-membered A-ring were designed and synthesized to mimic the A-ring diol structure of the natural hormone 1α,25-dihydroxyvitamin D3. Prepared from commercial 1,4-cyclohexanedione, a structurally simplified analog was designed and synthesized in which a suitably oriented primary allylic hydroxyl group at the C-2 position might be a surrogate for the biologically important 1α-OH in the natural hormone.
Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 8, 15 April 2005, Pages 2959–2966
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 8, 15 April 2005, Pages 2959–2966
نویسندگان
Gary H. Posner, S.H. Tony Lee, Hyung Jin Kim, Sara Peleg, Patrick Dolan, Thomas W. Kensler,