New naphthylcombretastatins. Modifications on the ethylene bridge

Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.

The synthesis and biological evaluation of naphthylcombretastatins, modified on the ethylene bridge, are described.Figure optionsDownload as PowerPoint slide