Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives

New analogs of desmosdumotin C (1), in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. Compounds 2–9, 13, and 16 were evaluated in vitro against human tumor cell replication. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.

New analogs of desmosdumotin C, in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.Figure optionsDownload as PowerPoint slide