Genotoxic activity of halogenated phenylglycine derivatives

The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

The discovery and synthesis of genotoxic (haloaryl)glycines is reported.Figure optionsDownload as PowerPoint slide