کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367720 | 981645 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents](/preview/png/1367720.png)
چکیده انگلیسی
A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25–2 μg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 μg/mL.
Out of the 20 compounds synthesized, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25–2 μg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 μg/mL.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 23, 1 December 2005, Pages 5218–5221
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 23, 1 December 2005, Pages 5218–5221
نویسندگان
Anu Agarwal, Kumkum Srivastava, S.K. Puri, S. Sinha, Prem M.S. Chauhan,