کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1368549 | 981701 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New indolizine–chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New indolizine–chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation New indolizine–chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation](/preview/png/1368549.png)
چکیده انگلیسی
A new family of indolizine–chalcones was designed, synthesized and screened for the inhibitory potential on human farnesyltransferase in vitro to identify potent antitumor agents. The most active compound was phenothiazine 2a, exhibiting an IC50 value in the low nanomolar range, similar to that of known FTI-276, highly potent farnesyltransferase inhibitor. The newly synthesized indolizine–chalcones 2a–d constitute the most efficient inhibitors of farnesyltransferase bearing a phenothiazine unit known to date.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3730–3734
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3730–3734
نویسندگان
Iuliana-Monica Moise, Alina Ghinet, Dalila Belei, Joëlle Dubois, Amaury Farce, Elena Bîcu,