کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1369200 | 981764 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 2-methoxybenzoylhydrazone and evaluation of their antileishmanial activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Compounds 1–25 showed varying degree of antileishmanial activities with IC50 values ranging between 1.95 and 88.56 μM. Compounds 2, 10, and 11 (IC50 = 3.29 ± 0.07 μM, 1.95 ± 0.04 μM, and 2.49 ± 0.03 μM, respectively) were found to be more active than standard pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 7 (IC50 = 7.64 ± 0.1 μM), 8 (IC50 = 13.17 ± 0.46 μM), 18 (IC50 = 13.15 ± 0.02 μM), and 24 (IC50 = 15.65 ± 0.41 μM) exhibited good activities. Compounds 1, 3, 4, 5, 9, 12, 15, 18, and 19 were found to be moderately active. Compounds 13, 14, 16, 17, 20–25 showed weak activities with IC50 values ranging between 57 and 88 μM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 11, 1 June 2013, Pages 3463–3466
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 11, 1 June 2013, Pages 3463–3466
نویسندگان
Muhammad Taha, Mohd Syukri Baharudin, Nor Hadiani Ismail, Khalid Mohammed Khan, Faridahanim Mohd Jaafar, Samreen, Salman Siddiqui, M. Iqbal Choudhary,