کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370092 981807 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, structure and in vitro cytostatic activity of ferrocene—Cinchona hybrids
ترجمه فارسی عنوان
سنتز، ساختار و فعالیت Cytostatic آزمایشگاهی هیبریدهای ferrocene-Cinchona
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Exploring copper(I)- and ruthenium(II)-catalyzed azide–alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 3, 1 February 2016, Pages 946–949
نویسندگان
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