Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin

Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale.

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► Hydrophobic tag-assisted liquid-phase peptide synthesis has been established.
► Disulfide bond formation has been combined with hydrophobic tag.
► A growth hormone-inhibiting peptide somatostatin has been prepared.
► Intramolecular cyclization proceeds under relatively high concentrations.