کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371034 | 981837 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Azachalcones: A new class of potent polyphenol oxidase inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Azachalcones: A new class of potent polyphenol oxidase inhibitors Azachalcones: A new class of potent polyphenol oxidase inhibitors](/preview/png/1371034.png)
چکیده انگلیسی
A library of potent inhibitors of polyphenol oxidase and their structure activity relationships are described. Azachalcone derivatives were synthesized and tested for their tyrosinase inhibitory activity. Their inhibitory activities on mushroom tyrosinase using l-DOPA as a substrate were investigated. Two compounds that are the reduction congeners of the pyridinyl azachalcones strongly inhibited the enzyme activity and were more potent than the positive control kojic acid.
X = N, Y = CH; IC50: 1.75 μM.X = CH, Y = N; IC50: 2.25 μM.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 8, 15 April 2015, Pages 1753–1756
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 8, 15 April 2015, Pages 1753–1756
نویسندگان
Sini Karanayil Radhakrishnan, Ronald Gibrial Shimmon, Costa Conn, Anthony T. Baker,