5-Oxo-15-HETE: Total synthesis and bioactivity

The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated with calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor.

The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated in the calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor.Figure optionsDownload as PowerPoint slide