کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372758 | 981881 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-Acylhydrazones as inhibitors of PDE10A
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
A series of hydrazone-based compounds was synthesized and shown to be novel, potent, and selective inhibitors against phosphodiesterase 10A (PDE10A). Compound 56 which was shown to have a statistically significant effect in two different behavioral models of schizophrenia.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 14, 15 July 2011, Pages 4155–4159
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 14, 15 July 2011, Pages 4155–4159
نویسندگان
Jennifer L. Gage, Rene Onrust, Derek Johnston, Andrew Osnowski, Wendy MacDonald, Lee Mitchell, László Ürögdi, Alex Rohde, Kevin Harbol, Sasha Gragerov, György Dormán, Tom Wheeler, Vince Florio, Neil S. Cutshall,