کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372933 | 981886 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flavonoids as inhibitors of human CD38
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Flavonoids as inhibitors of human CD38 Flavonoids as inhibitors of human CD38](/preview/png/1372933.png)
چکیده انگلیسی
CD38 is a multifunctional enzyme which is ubiquitously distributed in mammalian tissues. It is involved in the conversion of NAD(P)+ into cyclic ADP-ribose, NAADP+ and ADP-ribose and the role of these metabolites in multiple Ca2+ signaling pathways makes CD38 a novel potential pharmacological target. The dire paucity of CD38 inhibitors, however, renders the search for new molecular tools highly desirable. We report that human CD38 is inhibited at low micromolar concentrations by flavonoids such as luteolinidin, kuromanin and luteolin (IC50 <10 μM). Docking studies provide some clues on the mode of interaction of these molecules with the active site of CD38.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 3939–3942
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 13, 1 July 2011, Pages 3939–3942
نویسندگان
Esther Kellenberger, Isabelle Kuhn, Francis Schuber, Hélène Muller-Steffner,