Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors

A new sub-family of pyrrolotriazine analogs was identified as the potent VEGFR-2 kinase inhibitors. Antitumor efficacy was observed with compound 37 against L2987 human lung carcinoma xenografts in athymic mice.