کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373050 | 981888 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines](/preview/png/1373050.png)
چکیده انگلیسی
Diversely substituted 2-pyrrolines have been prepared by a novel multicomponent process involving a reaction of various N-(aryl- and alkylsulfonamido)-acetophenones with aldehydes and malononitrile. While the reaction is highly regioselective, it is not stereoselective, generating a mixture of cis and trans 2-pyrrolines. A number of analogs from both cis and trans 2-pyrroline libraries were found to have antiproliferative activity in human cancer cell lines.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 4, 15 February 2008, Pages 1392–1396
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 4, 15 February 2008, Pages 1392–1396
نویسندگان
Igor V. Magedov, Giovanni Luchetti, Nikolai M. Evdokimov, Madhuri Manpadi, Wim F.A. Steelant, Severine Van slambrouck, Paul Tongwa, Mikhail Yu. Antipin, Alexander Kornienko,