کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373302 | 981895 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors](/preview/png/1373302.png)
چکیده انگلیسی
A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude rat model.
Design and optimization of novel imidazopyridine derivatives led to the identification of a potent and selective PLK inhibitor 36.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4673–4678
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4673–4678
نویسندگان
Yoshiyuki Sato, Yu Onozaki, Tetsuya Sugimoto, Hideki Kurihara, Kaori Kamijo, Chie Kadowaki, Toshiaki Tsujino, Akiko Watanabe, Sachie Otsuki, Morihiro Mitsuya, Masato Iida, Kyosuke Haze, Takumitsu Machida, Yoko Nakatsuru, Hideya Komatani, Hidehito Kotani,