کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373343 981895 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
چکیده انگلیسی

We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of tumor cells by the fluorescent acetazolamide derivative and the ability of the albumin-binding acetazolamide derivative to cause tumor retardation in a SK-RC-52 xenograft model of cancer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 16, 15 August 2009, Pages 4851–4856
نویسندگان
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