کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373415 1500544 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
چکیده انگلیسی

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P2 portion led to the identification of compounds, such as 26, that have a unique selectivity profile against other cysteine proteases and offering new opportunities for safer treatment of Chagas disease.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 24, 15 December 2010, Pages 7444–7449
نویسندگان
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