کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373452 981898 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
چکیده انگلیسی

A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 14, 15 July 2007, Pages 3826–3830
نویسندگان
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