کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373525 981901 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Indole- and benzothiophene-based histamine H3 antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Indole- and benzothiophene-based histamine H3 antagonists
چکیده انگلیسی

Previous research on histamine H3 antagonists has led to the development of a pharmacophore model consisting of a central phenyl core flanked by two alkylamine groups. Recent investigation of the replacement of the central phenyl core with heteroaromatic fragments resulted in the preparation of novel 3,5-, 3,6- and 3,7-substituted indole and 3,5-substituted benzothiophene analogs that demonstrate good to excellent hH3 affinities. Select analogs were profiled in a rat pharmacokinetic model.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 21, 1 November 2010, Pages 6226–6230
نویسندگان
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