کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1373584 | 981903 | 2007 | 5 صفحه PDF | دانلود رایگان |
The non-covalent complexes of five bis-β-carbolines alkaloids with three different double-stranded oligodeoxynucleotides d(GCGCGATCGCGC)2, d(GCGCAATTGCGC)2, and d(GCGAAATTTCGC)2 were investigated by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. These five antitumor compounds all showed DNA-binding abilities. Binding affinities in the order of 2 > 3, 4 > 5, and 1 with double-stranded DNA were obtained, which mean that the length of the linkage chain between two β-carbolines has a remarkable effect on the formation of the non-covalent complexes. Additionally, the preliminary results indicated that bis-β-carbolines had no notable sequence selectivities.
The non-covalent complexes of five bis-β-carbolines 1-5 with three different 12-mer double-stranded oligodeoxynucleotides were investigated by ESI-FT-ICR MS. The structure–activity relationships and sequence selectivities were discussed.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 9, 1 May 2007, Pages 2549–2553