کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373678 1500606 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity
ترجمه فارسی عنوان
میکروسپرس های کیتوزان لاتین روتین: مشخص کردن و ارزیابی فعالیت ضد التهابی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Spray-dried chitosan microspheres allowed a massive encapsulation of rutin.
• Rutin-microspheres showed protective properties against inflammatory phenomena.
• The microencapsulation of rutin favored a massive cellular uptake of the drug.

Rutin was microencapsulated in a chitosan matrix using the spray-drying technique and the resulting system was investigated. High amounts of rutin were efficiently entrapped within polymeric microspheres, and these microparticles were characterized by a smooth surface and afforded a controlled release of the active compound. The anti-inflammatory activity of rutin-loaded microspheres was investigated in in vitro models of NCTC 2544 and C-28 cells treated with LPS by determining the levels of IL-1β and IL-6. The rutin-loaded microspheres showed an increase of in vitro anti-inflammatory activity with respect to the free active compound. Confocal laser scanning microscopy demonstrated that massive intracellular uptake of the chitosan microspheres took place after a few hours of incubation and that the drug was localized in the cytosol compartment of the treated cells. The improved anti-inflammatory activity of the rutin-loaded microspheres was further confirmed by an in vivo model of carrageenan-induced paw edema.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 152, 5 November 2016, Pages 583–591
نویسندگان
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