کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1373814 981906 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach
چکیده انگلیسی

We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.

A novel NR2B-selective NMDAR antagonist, LSP10-0500, was identified using a ligand-based virtual screening approach.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 18, 15 September 2010, Pages 5552–5558
نویسندگان
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