New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors

A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds.

A series of trifluoromethyl, benzothiazolyl and thiazolyl ketone-containing peptidic compounds were synthesized and evaluated in vitro against SARS-CoV 3CLpro.Figure optionsDownload as PowerPoint slide