کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374136 | 981913 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines](/preview/png/1374136.png)
چکیده انگلیسی
Structure–activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5451–5456
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 20, 15 October 2006, Pages 5451–5456
نویسندگان
Yuefen Zhou, Zhongxiang Sun, Jamie M. Froelich, Thomas Hermann, Daniel Wall,