کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1374477 | 981919 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and SAR of vinca alkaloid analogues
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and SAR of vinca alkaloid analogues Synthesis and SAR of vinca alkaloid analogues](/preview/png/1374477.png)
چکیده انگلیسی
Versatile intermediates 12′-iodovinblastine, 12′-iodovincristine and 11′-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell toxicity assays is presented. Selected analogues 27 and 36 show promising anticancer activity in the P388 murine leukemia model.
The development of selective iodination conditions for the dimeric vinca alkaloids vinblastine, vincristine, and semisynthetic derivative vinorelbine led to the preparation of new analogues of these important antitumor agents.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 4, 15 February 2009, Pages 1245–1249
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 4, 15 February 2009, Pages 1245–1249
نویسندگان
Matthew E. Voss, Jeffery M. Ralph, Dejian Xie, David D. Manning, Xinchao Chen, Anthony J. Frank, Andrew J. Leyhane, Lei Liu, Jason M. Stevens, Cheryl Budde, Matthew D. Surman, Thomas Friedrich, Denise Peace, Ian L. Scott, Mark Wolf, Randall Johnson,