کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1374730 | 981923 | 2006 | 4 صفحه PDF | دانلود رایگان |
EM703, which is an erythromycin derivative synthesized by our group, has a potent promoting activity of monocyte-to-macrophage differentiation in vitro. Its activity is approximately 300 times higher than that of erythromycin A (EM-A). In this study, we determined three-dimensional (3D) solution structures of EM703 and EM-A, and compared them using a superposition method, in order to investigate the 3D structure–activity relationship. We found a distinct difference between the 3D structures of these molecules, which might be an important factor in their divergent activities.
The three-dimensional structural features of EM703, which might be important for its potent promoting activity of monocyte-to-macrophage differentiation, are reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 9, 1 May 2006, Pages 2496–2499