کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375018 | 981931 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential scorpionate antibiotics: Targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The antibiotic vancomycin—that binds lipid II in the bacterial cell membrane—was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.
Vancomycin was conjugated to a hydrolysis catalyst (or TACzyme). Targeted hydrolysis by such a conjugate was observed using membranes containing lipid II. MIC-values of targeted hydrolysis catalyst constructs could be modulated by Zn(II).Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 14, 15 July 2009, Pages 3721–3724
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 14, 15 July 2009, Pages 3721–3724
نویسندگان
H. Bauke Albada, Christopher J. Arnusch, Hilbert M. Branderhorst, Anne-Marie Verel, Wouter T.M. Janssen, Eefjan Breukink, Ben de Kruijff, Roland J. Pieters, Rob M.J. Liskamp,