کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375036 981931 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting potential miRNA target sites within gene promoters
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Predicting potential miRNA target sites within gene promoters
چکیده انگلیسی

Synthetic small duplex RNAs that are complementary to gene promoters can activate or inhibit target gene expression. The potency and robustness of gene modulation by these RNAs suggests that natural mechanisms may exist to facilitate recognition of sequences within gene promoters by endogenous small RNAs. Here, we describe computational methods for identifying potential miRNA target sites within gene promoters. These methods will facilitate investigations of whether miRNAs interact with sequences outside of 3′-untranslated regions and suggest new targets for the design of synthetic modulators of gene expression.

A method for detecting potential microRNA target sites within gene promoters.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 14, 15 July 2009, Pages 3791–3794
نویسندگان
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