Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases

Pyrimido-oxazepine based sub-micromolar inhibitors (2–4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors.

The development of pyrimido-oxazepine based inhibitors for Aurora and FLT-3 is reported.Figure optionsDownload as PowerPoint slide